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What the FDA labels say about taking them together

Calcitriol and ketoconazole

Calcitriol's FDA label (Calcitriol) of July 10, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name calcitriol.

Check it at the source: the calcitriol FDA label on DailyMed (effective October 23, 2024, Amneal Pharmaceuticals LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).

What does the calcitriol label say about ketoconazole?

Calcitriol label (ANI Pharmaceuticals, Inc., July 10, 2026), drug interactions

Ketoconazole Ketoconazole may inhibit both synthetic and catabolic enzymes of calcitriol.

Source: FDA drug label (Calcitriol, NDA021068), ANI Pharmaceuticals, Inc., effective July 10, 2026 (SPL set bdb9c0d4-bdb3-4174-a4d9-55c423f38476), via openFDA

Source: FDA drug label (Calcitriol), Amneal Pharmaceuticals LLC, effective October 23, 2024 (SPL set b1fef137-63c5-4662-8cd9-b9e8b12bacb6), via openFDA; the full label on DailyMed

What does the ketoconazole label say about calcitriol?

Ketoconazole's label (effective January 28, 2026) does not name calcitriol in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

20Calcitriol generic labelers
30Ketoconazole generic labelers
CalcitriolKetoconazole
Labeled forPsoriasisFungal infections
Boxed warningNoNo
Pharmacy cost (NADAC)$0.153 per capsule 0.25 mcg capsule$0.249 per gram 2% cream
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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