What the FDA labels say about taking them together
Calcifediol and itraconazole
Calcifediol's FDA label of January 19, 2024 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name calcifediol. The calcifediol label: “CYP3A Inhibitors Cytochrome P450 inhibitors, such as ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin or voriconazole, may inhibit enzymes …”
Check it at the source: the calcifediol FDA label on DailyMed (effective January 19, 2024, OPKO Pharmaceuticals LLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the calcifediol label say about itraconazole?
Calcifediol label, drug interactionsCYP3A Inhibitors Cytochrome P450 inhibitors, such as ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin or voriconazole, may inhibit enzymes involved in vitamin D metabolism (CYP24A1 and CYP27B1), and may alter serum levels of calcifediol.
Source: FDA drug label (Rayaldee), NDA208010 (Eirgen), as published by OPKO Pharmaceuticals LLC, effective January 19, 2024 (SPL set 6a95effd-32a5-46b6-a30e-7f4f9bf8cc77), via openFDA; the full label on DailyMed
What does the itraconazole label say about calcifediol?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name calcifediol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcifediol | Itraconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $41.26 per capsule 30 mcg capsule (hard) | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once