What the FDA labels say about taking them together
Caffeine and venlafaxine
Venlafaxine's FDA label (Venlafaxine Hydrochloride) of July 31, 2025 names caffeine in its drug interactions section; the caffeine labels PlainMeds reads (2) do not name venlafaxine.
Check it at the source: the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals); the venlafaxine FDA label on DailyMed (effective August 15, 2023, Viatris Specialty LLC).
What does the caffeine label say about venlafaxine?
Caffeine's label (effective July 29, 2026) and its 1 other brand-application label do not name venlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
What does the venlafaxine label say about caffeine?
Venlafaxine Hydrochloride label (Trigen Laboratories, LLC, July 31, 2025), drug interactionsThis finding was confirmed in vivo by a clinical drug interaction study in which venlafaxine did not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Source: FDA drug label (Venlafaxine Hydrochloride, NDA022104), Trigen Laboratories, LLC, effective July 31, 2025 (SPL set fdaed1c2-dd0a-4bf3-975a-86fe3e7f0c97), via openFDA
Source: FDA drug label (Effexor XR), NDA020699 (Upjohn), as published by Viatris Specialty LLC, effective August 15, 2023 (SPL set c848a5d8-ba94-4c84-80e3-0bf35fb8e32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caffeine | Venlafaxine | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.083 per tablet 200 mg tablet | $0.0799 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once