What the FDA labels say about taking them together
Caffeine and tranylcypromine
Tranylcypromine's FDA label of July 2, 2025 names caffeine in its drug interactions section; the caffeine labels PlainMeds reads (2) do not name tranylcypromine. The tranylcypromine label: “… pasteurized so as to allow for ongoing fermentation and excessive amounts of caffeine.; Acceptable Foods and Drinks, Containing No or Little Tyramine: Concomitant use of alcohol with PARNATE is not recommended.”
Check it at the source: the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the caffeine label say about tranylcypromine?
Caffeine's label (effective July 29, 2026) and its 1 other brand-application label do not name tranylcypromine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about caffeine?
Tranylcypromine label, drug interactionsClass of Food or Beverage: Beverages; Tyramine-Rich Foods and Beverages to Avoid: All varieties of tap beer and beers that have not been pasteurized so as to allow for ongoing fermentation and excessive amounts of caffeine.; Acceptable Foods and Drinks, Containing No or Little Tyramine: Concomitant use of alcohol with PARNATE is not recommended. (Bottled and canned beers and wines contain little or no tyramine.)
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caffeine | Tranylcypromine | |
|---|---|---|
| Labeled for | n/a | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.083 per tablet 200 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once