What the FDA labels say about taking them together
Caffeine and stiripentol
Stiripentol's FDA label of April 27, 2026 names caffeine in its drug interactions section; the caffeine labels PlainMeds reads (2) do not name stiripentol. The stiripentol label: “Because of potential drug-drug interactions, consider dose adjustment of CYP1A2 substrates, CYP2B6 substrates, and CYP3A4 substrates, as clinically appropriate, when administered concomitantly with DIACOMIT.”
Check it at the source: the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).
What does the caffeine label say about stiripentol?
Caffeine's label (effective July 29, 2026) and its 1 other brand-application label do not name stiripentol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
What does the stiripentol label say about caffeine?
Stiripentol label, drug interactionsBecause of potential drug-drug interactions, consider dose adjustment of CYP1A2 substrates (e.g., theophylline, caffeine), CYP2B6 substrates (e.g., sertraline, thiotepa), and CYP3A4 substrates (e.g., midazolam, triazolam, quinidine), as clinically appropriate, when administered concomitantly with DIACOMIT.
Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caffeine | Stiripentol | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.083 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once