What the FDA labels say about taking them together
Caffeine and pentoxifylline
Pentoxifylline's FDA label of May 15, 2026 names caffeine in its contraindications section; the caffeine labels PlainMeds reads (2) do not name pentoxifylline. The pentoxifylline label: “… previously exhibited intolerance to this product or methylxanthines such as caffeine, theophylline, and theobromine.”
Check it at the source: the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals); the pentoxifylline FDA label on DailyMed (effective May 15, 2026, Rising Pharma Holdings, Inc.).
What does the caffeine label say about pentoxifylline?
Caffeine's label (effective July 29, 2026) and its 1 other brand-application label do not name pentoxifylline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
What does the pentoxifylline label say about caffeine?
Pentoxifylline label, contraindicationsCONTRAINDICATIONS Pentoxifylline extended-release tablets should not be used in patients with recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to this product or methylxanthines such as caffeine, theophylline, and theobromine.
Source: FDA drug label (Pentoxifylline), Rising Pharma Holdings, Inc., effective May 15, 2026 (SPL set cd840a2c-2a0e-4b2b-84ff-a0406bb6fa37), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caffeine | Pentoxifylline | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.083 per tablet 200 mg tablet | $0.227 per tablet 400 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once