What the FDA labels say about taking them together
Caffeine and enasidenib
Enasidenib's FDA label of January 16, 2025 names caffeine in its drug interactions section; the caffeine labels PlainMeds reads (2) do not name enasidenib. The enasidenib label: “Consider reducing the frequency of caffeine intake from various food and beverages in a 24 hour period while taking IDHIFA because IDHIFA may increase the effect of caffeine in patients who are sensitive to it.”
Check it at the source: the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals); the enasidenib FDA label on DailyMed (effective January 16, 2025, Celgene Corporation).
What does the caffeine label say about enasidenib?
Caffeine's label (effective July 29, 2026) and its 1 other brand-application label do not name enasidenib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
What does the enasidenib label say about caffeine?
Enasidenib label, drug interactionsConsider reducing the frequency of caffeine intake from various food and beverages in a 24 hour period while taking IDHIFA because IDHIFA may increase the effect of caffeine in patients who are sensitive to it.
Source: FDA drug label (Idhifa), NDA209606 (Bristol Myers Squibb), as published by Celgene Corporation, effective January 16, 2025 (SPL set a5b4cdf0-3fa8-4c6c-80f6-8d8a00e3a5b6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caffeine | Enasidenib | |
|---|---|---|
| Labeled for | n/a | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.083 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once