What the FDA labels say about taking them together
Cabozantinib and nivolumab
Cabozantinib's FDA label of October 19, 2025 names nivolumab in its warnings and precautions section, and nivolumab's label names cabozantinib too. The nivolumab label: “OPDIVO with Cabozantinib OPDIVO in combination with cabozantinib can cause hepatic toxicity with higher frequencies of Grade 3 and 4 ALT and AST elevations compared to OPDIVO alone.”
Check it at the source: the cabozantinib FDA label on DailyMed (effective October 19, 2025, Exelixis, Inc.); the nivolumab FDA label on DailyMed (effective August 12, 2026, E.R. Squibb & Sons, L.L.C.).
What does the cabozantinib label say about nivolumab?
Cabozantinib label, warnings and precautionsWhen used in combination with nivolumab, higher frequencies of Grade 3 and 4 ALT and AST elevation may occur than with CABOMETYX alone.
Source: FDA drug label (CABOMETYX), Exelixis, Inc., effective October 19, 2025 (SPL set 3850cce2-6137-42e5-a792-d318c4a4b3b5), via openFDA; the full label on DailyMed
What does the nivolumab label say about cabozantinib?
Nivolumab label, warnings and precautionsOPDIVO with Cabozantinib OPDIVO in combination with cabozantinib can cause hepatic toxicity with higher frequencies of Grade 3 and 4 ALT and AST elevations compared to OPDIVO alone.
Source: FDA drug label (OPDIVO), E.R. Squibb & Sons, L.L.C., effective August 12, 2026 (SPL set f570b9c4-6846-4de2-abfa-4d0a4ae4e394), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cabozantinib | Nivolumab | |
|---|---|---|
| Labeled for | n/a | Lung cancer, Leukemia, lymphoma and myeloma, Colorectal cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once