What the FDA labels say about taking them together
Cabozantinib and lamivudine
Cabozantinib's FDA label (Cometriq) of October 18, 2025 names lamivudine in its drug interactions section; the lamivudine labels PlainMeds reads (2) do not name cabozantinib. The cabozantinib label: “Monitor patients for increased toxicity when MRP2 inhibitors are co-administered with COMETRIQ.”
Check it at the source: the cabozantinib FDA label on DailyMed (effective October 19, 2025, Exelixis, Inc.); the lamivudine FDA label on DailyMed (effective January 5, 2026, Strides Pharma Science Limited).
What does the cabozantinib label say about lamivudine?
Cometriq label (Exelixis, Inc., October 18, 2025), drug interactionsMonitor patients for increased toxicity when MRP2 inhibitors (e.g., abacavir, adefovir, cidofovir, furosemide, lamivudine, nevirapine, ritonavir, probenecid, saquinavir, and tenofovir) are co-administered with COMETRIQ [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Cometriq, NDA203756), Exelixis, Inc., effective October 18, 2025 (SPL set 1a0c3bea-c87b-4d25-bb44-5f0174da6b34), via openFDA
Source: FDA drug label (CABOMETYX), Exelixis, Inc., effective October 19, 2025 (SPL set 3850cce2-6137-42e5-a792-d318c4a4b3b5), via openFDA; the full label on DailyMed
What does the lamivudine label say about cabozantinib?
Lamivudine's label (effective January 5, 2026) and its 1 other brand-application label do not name cabozantinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lamivudine), Strides Pharma Science Limited, effective January 5, 2026 (SPL set ac824c7e-9c9f-487b-ad2f-d50eaef5cbda), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cabozantinib | Lamivudine | |
|---|---|---|
| Labeled for | n/a | HIV, Hepatitis B |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.489 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once