What the FDA labels say about taking them together

Cabozantinib and cidofovir

Cabozantinib's FDA label (Cometriq) of October 18, 2025 names cidofovir in its drug interactions section; the cidofovir label PlainMeds reads does not name cabozantinib. The cabozantinib label: “Monitor patients for increased toxicity when MRP2 inhibitors are co-administered with COMETRIQ.”

Check it at the source: the cabozantinib FDA label on DailyMed (effective October 19, 2025, Exelixis, Inc.); the cidofovir FDA label on DailyMed (effective October 25, 2023, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).

What does the cabozantinib label say about cidofovir?

Cometriq label (Exelixis, Inc., October 18, 2025), drug interactions
Monitor patients for increased toxicity when MRP2 inhibitors (e.g., abacavir, adefovir, cidofovir, furosemide, lamivudine, nevirapine, ritonavir, probenecid, saquinavir, and tenofovir) are co-administered with COMETRIQ [see Clinical Pharmacology ( 12.3 )].

Source: FDA drug label (Cometriq, NDA203756), Exelixis, Inc., effective October 18, 2025 (SPL set 1a0c3bea-c87b-4d25-bb44-5f0174da6b34), via openFDA

Source: FDA drug label (CABOMETYX), Exelixis, Inc., effective October 19, 2025 (SPL set 3850cce2-6137-42e5-a792-d318c4a4b3b5), via openFDA; the full label on DailyMed

What does the cidofovir label say about cabozantinib?

Cidofovir's label (effective October 25, 2023) does not name cabozantinib in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (CIDOFOVIR DIHYDRATE), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective October 25, 2023 (SPL set 44966a7e-d777-40fb-956f-d0f31f737848), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Cabozantinib generic labelers

2Cidofovir generic labelers

	Cabozantinib	Cidofovir
Labeled for	n/a	n/a
Boxed warning	No	Yes
Pharmacy cost (NADAC)	n/a	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Cabozantinib: the full record
Cidofovir: the full record
Check more medicines together: up to five at once