What the FDA labels say about taking them together
Butorphanol and oliceridine
Oliceridine's FDA label of December 31, 2025 names butorphanol in its drug interactions section; the butorphanol label PlainMeds reads does not name oliceridine. The oliceridine label: “May reduce the analgesic effect of OLINVYK and/or precipitate withdrawal symptoms.”
Check it at the source: the butorphanol FDA label on DailyMed (effective January 2, 2026, Hospira, Inc.); the oliceridine FDA label on DailyMed (effective December 31, 2025, Trevena, Inc.).
What does the butorphanol label say about oliceridine?
Butorphanol's label (effective January 2, 2026) does not name oliceridine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Butorphanol Tartrate), Hospira, Inc., effective January 2, 2026 (SPL set 9822ca3f-aee2-46e5-8a96-495400e65d10), via openFDA; the full label on DailyMed
What does the oliceridine label say about butorphanol?
Oliceridine label, drug interactionsClinical Impact: May reduce the analgesic effect of OLINVYK and/or precipitate withdrawal symptoms. Intervention: Avoid concomitant use. Examples: butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants
Oliceridine label, warnings and precautionsAdditionally, avoid the use of mixed agonist/antagonist (e.g, pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including OLINVYK.
Source: FDA drug label (OLINVYK), Trevena, Inc., effective December 31, 2025 (SPL set ce167984-8b9d-40b7-84ce-d0f33fff1eaa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Butorphanol | Oliceridine | |
|---|---|---|
| Labeled for | Pain | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $15.46 per mL 10 mg/mL spray | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once