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What the FDA labels say about taking them together

Buspirone and deferasirox

Deferasirox's FDA label of January 28, 2026 names buspirone in its drug interactions section; the buspirone label PlainMeds reads does not name deferasirox. The deferasirox label: “Closely monitor patients for signs of reduced effectiveness when deferasirox is administered with drugs metabolized by CYP3A4.”

Check it at the source: the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.); the deferasirox FDA label on DailyMed (effective January 28, 2026, Novartis Pharmaceuticals Corporation).

What does the buspirone label say about deferasirox?

Buspirone's label (effective December 22, 2023) does not name deferasirox in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed

What does the deferasirox label say about buspirone?

Deferasirox label, drug interactions

Closely monitor patients for signs of reduced effectiveness when deferasirox is administered with drugs metabolized by CYP3A4 (e.g., alfentanil, aprepitant, budesonide, buspirone, conivaptan, cyclosporine, darifenacin, darunavir, dasatinib, dihydroergotamine, dronedarone, eletriptan, eplerenone, ergotamine, everolimus, felodipine, fentanyl, hormonal contraceptive agents, indinavir, fluticasone, lopinavir, lovastatin, lurasidone, maraviroc, midazolam, nisoldipine, pimozide, quetiapine, quinidine, saquinavir, sildenafil, simvastatin, sirolimus, tacrolimus, tolvaptan, tipranavir, triazolam, ticagrelor, and vardenafil) [see Clinical Pharmacology (12.3)].

Source: FDA drug label (Exjade), Novartis Pharmaceuticals Corporation, effective January 28, 2026 (SPL set 3495a70c-870c-4968-940e-8baea152cf85), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

47Buspirone generic labelers
20Deferasirox generic labelers
BuspironeDeferasirox
Labeled forAnxietyn/a
Boxed warningNoYes
Pharmacy cost (NADAC)$0.043 per tablet 15 mg tablet$1.25 per tablet 360 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?