What the FDA labels say about taking them together
Buspirone and cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil's FDA label of February 4, 2025 names buspirone in its drug interactions section; the buspirone label PlainMeds reads does not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil. The cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label: “Coadministration of parenteral midazolam with STRIBILD should be done in a setting that ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation. …”
Check it at the source: the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.); the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil FDA label on DailyMed (effective February 4, 2025, Gilead Sciences, Inc.).
What does the buspirone label say about cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil?
Buspirone's label (effective December 22, 2023) does not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed
What does the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label say about buspirone?
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label, drug interactionsConcomitant Drug Class/Drug Name: Other benzodiazepines: e.g., parenterally administered midazolam clorazepate diazepam estazolam flurazepam buspirone zolpidem; Effect on Concentration ↑=Increase, ↓=Decrease: ↑ sedatives/hypnotics; Clinical Comment: Coadministration of parenteral midazolam with STRIBILD should be done in a setting that ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation. Dosage reduction for midazolam should be considered, especially if more than a single dose of midazolam is administered. With other sedative/hypnotics, dose reduction may be necessary and clinical monitoring is recommended.
Source: FDA drug label (Stribild), Gilead Sciences, Inc., effective February 4, 2025 (SPL set 74ae2a93-b267-444c-8f0f-a2a6522260ee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Buspirone | Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil | |
|---|---|---|
| Labeled for | Anxiety | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.043 per tablet 15 mg tablet | $150.14 per tablet Stribild tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once