What the FDA labels say about taking them together
Buspirone and clomipramine
Clomipramine's FDA label of November 26, 2024 names buspirone in its warnings section; the buspirone label PlainMeds reads does not name clomipramine. The clomipramine label: “Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including clomipramine hydrochloride capsules, alone but particularly with concomitant use …”
Check it at the source: the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.); the clomipramine FDA label on DailyMed (effective November 26, 2024).
What does the buspirone label say about clomipramine?
Buspirone's label (effective December 22, 2023) does not name clomipramine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed
What does the clomipramine label say about buspirone?
Clomipramine label, warningsSerotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including clomipramine hydrochloride capsules, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort) and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Source: FDA drug label (CLOMIPRAMINE HYDROCHLORIDE), SpecGx LLC, effective November 26, 2024 (SPL set d7cee3fa-d05c-4702-8f75-f446627bdb49), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Buspirone | Clomipramine | |
|---|---|---|
| Labeled for | Anxiety | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.043 per tablet 15 mg tablet | $0.189 per capsule 25 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once