What the FDA labels say about taking them together
Buspirone and cimetidine
Buspirone's FDA label of December 22, 2023 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name buspirone. The buspirone label: “Other Drugs Cimetidine Coadministration of buspirone with cimetidine was found to increase C max (40%) and T max (2 fold), but had minimal effects on the AUC of buspirone.”
Check it at the source: the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.); the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the buspirone label say about cimetidine?
Buspirone label, drug interactionsOther Drugs Cimetidine Coadministration of buspirone with cimetidine was found to increase C max (40%) and T max (2 fold), but had minimal effects on the AUC of buspirone.
Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed
What does the cimetidine label say about buspirone?
Cimetidine's label (effective July 15, 2026) does not name buspirone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Buspirone | Cimetidine | |
|---|---|---|
| Labeled for | Anxiety | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.043 per tablet 15 mg tablet | $0.236 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once