What the FDA labels say about taking them together
Burosumab and paricalcitol
Burosumab's FDA label of April 22, 2026 names paricalcitol in its contraindications section; the paricalcitol labels PlainMeds reads (4) do not name burosumab. The burosumab label: “CONTRAINDICATIONS CRYSVITA is contraindicated: In concomitant use with oral phosphate and/or active vitamin D analogs due to the risk of hyperphosphatemia.”
Check it at the source: the burosumab FDA label on DailyMed (effective April 22, 2026); the paricalcitol FDA label on DailyMed (effective August 7, 2024, AbbVie Inc.).
What does the burosumab label say about paricalcitol?
Burosumab label, contraindicationsCONTRAINDICATIONS CRYSVITA is contraindicated: In concomitant use with oral phosphate and/or active vitamin D analogs (e.g. calcitriol, paricalcitol, doxercalciferol, calcifediol) due to the risk of hyperphosphatemia [see Warnings and Precautions (5.2) and Drug Interactions (7.1) ].
Source: FDA drug label (CRYSVITA), Kyowa Kirin, Inc., effective April 22, 2026 (SPL set 102f96a0-6e3a-4fc1-b204-34d604683af6), via openFDA; the full label on DailyMed
What does the paricalcitol label say about burosumab?
Paricalcitol's label (effective August 7, 2024) and its 3 other brand-application labels do not name burosumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zemplar), AbbVie Inc., effective August 7, 2024 (SPL set 1b27c026-2d60-47b4-2a9c-ded1818f21b5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Burosumab | Paricalcitol | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.28 per capsule 1 mcg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once