What the FDA labels say about taking them together
Burosumab and calcitriol
Burosumab's FDA label of April 22, 2026 names calcitriol in its contraindications section; the calcitriol labels PlainMeds reads (3) do not name burosumab. The burosumab label: “CONTRAINDICATIONS CRYSVITA is contraindicated: In concomitant use with oral phosphate and/or active vitamin D analogs due to the risk of hyperphosphatemia.”
Check it at the source: the burosumab FDA label on DailyMed (effective April 22, 2026); the calcitriol FDA label on DailyMed (effective October 23, 2024, Amneal Pharmaceuticals LLC).
What does the burosumab label say about calcitriol?
Burosumab label, contraindicationsCONTRAINDICATIONS CRYSVITA is contraindicated: In concomitant use with oral phosphate and/or active vitamin D analogs (e.g. calcitriol, paricalcitol, doxercalciferol, calcifediol) due to the risk of hyperphosphatemia [see Warnings and Precautions (5.2) and Drug Interactions (7.1) ].
Source: FDA drug label (CRYSVITA), Kyowa Kirin, Inc., effective April 22, 2026 (SPL set 102f96a0-6e3a-4fc1-b204-34d604683af6), via openFDA; the full label on DailyMed
What does the calcitriol label say about burosumab?
Calcitriol's label (effective October 23, 2024) and its 2 other brand-application labels do not name burosumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Calcitriol), Amneal Pharmaceuticals LLC, effective October 23, 2024 (SPL set b1fef137-63c5-4662-8cd9-b9e8b12bacb6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Burosumab | Calcitriol | |
|---|---|---|
| Labeled for | n/a | Psoriasis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.153 per capsule 0.25 mcg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once