What the FDA labels say about taking them together
Bupropion/dextromethorphan and nicotine
Bupropion/dextromethorphan's FDA label of August 17, 2026 names nicotine in its warnings and precautions section; the nicotine labels PlainMeds reads (2) do not name bupropion/dextromethorphan. The bupropion/dextromethorphan label: “Monitor blood pressure in patients who receive the combination of bupropion and nicotine replacement.”
Check it at the source: the bupropion/dextromethorphan FDA label on DailyMed (effective August 17, 2026, Axsome Therapeutics, Inc.); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the bupropion/dextromethorphan label say about nicotine?
Bupropion/dextromethorphan label, warnings and precautionsMonitor blood pressure in patients who receive the combination of bupropion and nicotine replacement.
Source: FDA drug label (AUVELITY), Axsome Therapeutics, Inc., effective August 17, 2026 (SPL set dcefda7c-9a68-278e-e053-2995a90aec79), via openFDA; the full label on DailyMed
What does the nicotine label say about bupropion/dextromethorphan?
Nicotine's label (effective July 25, 2024) and its 1 other brand-application label do not name bupropion/dextromethorphan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion/dextromethorphan | Nicotine | |
|---|---|---|
| Labeled for | Depression | Quitting smoking |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $19.90 per tablet 45-105 mg tablet | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once