What the FDA labels say about taking them together
Buprenorphine and oliceridine
Oliceridine's FDA label of December 31, 2025 names buprenorphine in its drug interactions section; the buprenorphine labels PlainMeds reads (4) do not name oliceridine. The oliceridine label: “May reduce the analgesic effect of OLINVYK and/or precipitate withdrawal symptoms.”
Check it at the source: the buprenorphine FDA label on DailyMed (effective June 5, 2026); the oliceridine FDA label on DailyMed (effective December 31, 2025, Trevena, Inc.).
What does the buprenorphine label say about oliceridine?
Buprenorphine's label (effective June 5, 2026) and its 3 other brand-application labels do not name oliceridine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buprenorphine HCl), SpecGx LLC, effective June 5, 2026 (SPL set b60d514d-a88a-4fa2-a5b0-30ac29e04973), via openFDA; the full label on DailyMed
What does the oliceridine label say about buprenorphine?
Oliceridine label, drug interactionsClinical Impact: May reduce the analgesic effect of OLINVYK and/or precipitate withdrawal symptoms. Intervention: Avoid concomitant use. Examples: butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants
Oliceridine label, warnings and precautionsAdditionally, avoid the use of mixed agonist/antagonist (e.g, pentazocine, nalbuphine, and butorphanol) or partial agonist (e.g., buprenorphine) analgesics in patients who are receiving a full opioid agonist analgesic, including OLINVYK.
Source: FDA drug label (OLINVYK), Trevena, Inc., effective December 31, 2025 (SPL set ce167984-8b9d-40b7-84ce-d0f33fff1eaa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Buprenorphine | Oliceridine | |
|---|---|---|
| Labeled for | Opioid use disorder, Pain | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.277 per tablet 2 mg tablet sl | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once