What the FDA labels say about taking them together
Budesonide and cyclosporine
Budesonide's FDA label (Eohilia) of February 3, 2025 names cyclosporine in its drug interactions section; cyclosporine's label does not name budesonide itself but warns about its class (Corticosteroids). The budesonide label: “Inhibitors of CYP3A4 can increase systemic budesonide concentrations.”
Check it at the source: the budesonide FDA label on DailyMed (effective October 11, 2019, AstraZeneca Pharmaceuticals LP); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the budesonide label say about cyclosporine?
Eohilia label (TAKEDA PHARMACEUTICALS AMERICA, INC., February 3, 2025), drug interactionsConcomitant use of budesonide with CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, cyclosporine, grapefruit juice) can increase systemic budesonide concentrations [see Clinical Pharmacology (12.3) ].
Tarpeyo label (Calliditas Therapeutics AB, January 21, 2026), drug interactionsAvoid use with potent CYP3A4 inhibitors; e.g. ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, and cyclosporine [see Clinical Pharmacology ( 12.3 )].
Budesonide label (Padagis US LLC, June 5, 2024), drug interactionsInhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, and cyclosporine) can increase systemic budesonide concentrations [see Clinical Pharmacology (12.3)].
Source: FDA drug label (Eohilia, NDA213976), TAKEDA PHARMACEUTICALS AMERICA, INC., effective February 3, 2025 (SPL set 56f2023a-69b2-4470-b4ad-af7ec1be527a), via openFDA
Source: FDA drug label (Tarpeyo, NDA215935), Calliditas Therapeutics AB, effective January 21, 2026 (SPL set 938cada4-d6bf-4252-836f-dd40f9eadb4d), via openFDA
Source: FDA drug label (Budesonide, NDA021324), Padagis US LLC, effective June 5, 2024 (SPL set 3a18d5a7-04c5-4137-8155-70a8adc0a48b), via openFDA
Source: FDA drug label (PULMICORT RESPULES), AstraZeneca Pharmaceuticals LP, effective October 11, 2019 (SPL set 33cd9834-76df-4f26-3fa2-aab6b9eee8f2), via openFDA; the full label on DailyMed
What does the cyclosporine label say about budesonide?
Cyclosporine's label does not name budesonide itself; it warns about its class (Corticosteroids):
Cyclosporine label, warningsPredisposing factors, such as hypertension, hypomagnesemia, hypocholesterolemia, high-dose corticosteroids, high cyclosporine blood concentrations, and graft-versus-host disease, have been noted in many but not all of the reported cases.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Budesonide | Cyclosporine | |
|---|---|---|
| Labeled for | Asthma, Allergies, Crohn's disease and ulcerative colitis | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.498 per capsule 3 mg capsule | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once