What the FDA labels say about taking them together
Bromocriptine and clozapine
Bromocriptine's FDA label (Cycloset) of January 12, 2026 names clozapine in its warnings and precautions section; the clozapine labels PlainMeds reads (2) do not name bromocriptine. The bromocriptine label: “Dopamine receptor antagonists, including neuroleptic agents that have dopamine D2 receptor antagonist properties, may reduce the effectiveness of CYCLOSET, and CYCLOSET may reduce the effectiveness of these agents.”
Check it at the source: the bromocriptine FDA label on DailyMed (effective July 27, 2026, ANI Pharmaceuticals, Inc.); the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.).
What does the bromocriptine label say about clozapine?
Cycloset label (Avvisto Therapeutics LLC, January 12, 2026), warnings and precautionsDopamine receptor antagonists, including neuroleptic agents that have dopamine D2 receptor antagonist properties (e.g., clozapine, olanzapine, ziprasidone), may reduce the effectiveness of CYCLOSET, and CYCLOSET may reduce the effectiveness of these agents.
Source: FDA drug label (Cycloset, NDA020866), Avvisto Therapeutics LLC, effective January 12, 2026 (SPL set e42ba916-16b9-4d1c-8d09-9d2fbb1b6c20), via openFDA
Source: FDA drug label (Bromocriptine Mesylate), ANI Pharmaceuticals, Inc., effective July 27, 2026 (SPL set 17f3a343-1782-4799-95ba-31dfe93be2cf), via openFDA; the full label on DailyMed
What does the clozapine label say about bromocriptine?
Clozapine's label (effective June 6, 2025) and its 1 other brand-application label do not name bromocriptine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bromocriptine | Clozapine | |
|---|---|---|
| Labeled for | Parkinson's disease, Type 2 diabetes | Schizophrenia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.61 per tablet 2.5 mg tablet | $0.610 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once