What the FDA labels say about taking them together
Brincidofovir and cyclosporine
Brincidofovir's FDA label of July 1, 2025 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name brincidofovir. The brincidofovir label: “Drugs on TEMBEXA Inhibitors for Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Concomitant use of TEMBEXA with OATP1B1 and 1B3 inhibitors increase brincidofovir AUC and C max which may increase …”
Check it at the source: the brincidofovir FDA label on DailyMed (effective July 1, 2025, Emergent BioDefense Operations Lansing LLC); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the brincidofovir label say about cyclosporine?
Brincidofovir label, drug interactionsDrugs on TEMBEXA Inhibitors for Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Concomitant use of TEMBEXA with OATP1B1 and 1B3 inhibitors (clarithromycin, cyclosporine, erythromycin, gemfibrozil, human immunodeficiency virus [HIV] and hepatitis C virus [HCV] protease inhibitors, rifampin [single dose]) increase brincidofovir AUC and C max which may increase TEMBEXA-associated adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Tembexa), Emergent BioDefense Operations Lansing LLC, effective July 1, 2025 (SPL set 209aa94b-c613-4880-ad89-41be83d12c0a), via openFDA; the full label on DailyMed
What does the cyclosporine label say about brincidofovir?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name brincidofovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Brincidofovir | Cyclosporine | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once