What the FDA labels say about taking them together
Brincidofovir and clarithromycin
Brincidofovir's FDA label of July 1, 2025 names clarithromycin in its drug interactions section; the clarithromycin label PlainMeds reads does not name brincidofovir. The brincidofovir label: “Drugs on TEMBEXA Inhibitors for Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Concomitant use of TEMBEXA with OATP1B1 and 1B3 inhibitors increase brincidofovir AUC and C max which may increase …”
Check it at the source: the brincidofovir FDA label on DailyMed (effective July 1, 2025, Emergent BioDefense Operations Lansing LLC); the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation).
What does the brincidofovir label say about clarithromycin?
Brincidofovir label, drug interactionsDrugs on TEMBEXA Inhibitors for Organic Anion Transporting Polypeptide (OATP) 1B1 and 1B3 Concomitant use of TEMBEXA with OATP1B1 and 1B3 inhibitors (clarithromycin, cyclosporine, erythromycin, gemfibrozil, human immunodeficiency virus [HIV] and hepatitis C virus [HCV] protease inhibitors, rifampin [single dose]) increase brincidofovir AUC and C max which may increase TEMBEXA-associated adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Tembexa), Emergent BioDefense Operations Lansing LLC, effective July 1, 2025 (SPL set 209aa94b-c613-4880-ad89-41be83d12c0a), via openFDA; the full label on DailyMed
What does the clarithromycin label say about brincidofovir?
Clarithromycin's label (effective April 9, 2026) does not name brincidofovir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Brincidofovir | Clarithromycin | |
|---|---|---|
| Labeled for | n/a | Bacterial infections, Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.466 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once