What the FDA labels say about taking them together
Brexpiprazole and risperidone
Brexpiprazole's FDA label of May 6, 2026 names risperidone in its warnings and precautions section; risperidone's label does not name brexpiprazole itself but warns about its class (Atypical antipsychotics).
Check it at the source: the brexpiprazole FDA label on DailyMed (effective May 6, 2026, Otsuka America Pharmaceutical, Inc.); the risperidone FDA label on DailyMed (effective May 28, 2026, Janssen Pharmaceuticals, Inc.).
What does the brexpiprazole label say about risperidone?
Brexpiprazole label, warnings and precautionsStroke in Elderly Patients with Dementia-Related Psychosis In placebo-controlled trials in elderly patients with dementia, patients randomized to risperidone, aripiprazole, and olanzapine had a higher incidence of stroke and transient ischemic attack, including fatal stroke.
Source: FDA drug label (Rexulti), Otsuka America Pharmaceutical, Inc., effective May 6, 2026 (SPL set 2d301358-6291-4ec1-bd87-37b4ad9bd850), via openFDA; the full label on DailyMed
What does the risperidone label say about brexpiprazole?
Risperidone's label does not name brexpiprazole itself; it warns about its class (Atypical antipsychotics):
Risperidone label, boxed warningINCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Risperidone label, boxed warningElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Source: FDA drug label (RISPERDAL), Janssen Pharmaceuticals, Inc., effective May 28, 2026 (SPL set 7e117c7e-02fc-4343-92a1-230061dfc5e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Brexpiprazole | Risperidone | |
|---|---|---|
| Labeled for | Depression, Schizophrenia | Bipolar disorder, Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $49.50 per tablet 0.25 mg tablet | $0.0368 per tablet 0.25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once