What the FDA labels say about taking them together
Brexpiprazole and dextromethorphan
Brexpiprazole's FDA label of May 6, 2026 names dextromethorphan in its drug interactions section; the dextromethorphan label PlainMeds reads does not name brexpiprazole. The brexpiprazole label: “Concomitant use of REXULTI and a strong CYP3A4 inducer decreased the exposure of brexpiprazole compared to the use of REXULTI alone.”
Check it at the source: the brexpiprazole FDA label on DailyMed (effective May 6, 2026, Otsuka America Pharmaceutical, Inc.); the dextromethorphan FDA label on DailyMed (effective August 27, 2026).
What does the brexpiprazole label say about dextromethorphan?
Brexpiprazole label, drug interactionsClinical Impact: Concomitant use of REXULTI and a strong CYP3A4 inducer decreased the exposure of brexpiprazole compared to the use of REXULTI alone. … gastric pH modifiers (e.g., omeprazole). Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.
Source: FDA drug label (Rexulti), Otsuka America Pharmaceutical, Inc., effective May 6, 2026 (SPL set 2d301358-6291-4ec1-bd87-37b4ad9bd850), via openFDA; the full label on DailyMed
What does the dextromethorphan label say about brexpiprazole?
Dextromethorphan's label (effective August 27, 2026) does not name brexpiprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Good Sense Cough DM), L. Perrigo Company, effective August 27, 2026 (SPL set 5a2e9bef-42cb-4b72-9a26-c3ae71dcb4ea), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Brexpiprazole | Dextromethorphan | |
|---|---|---|
| Labeled for | Depression, Schizophrenia | Cough and cold |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $49.50 per tablet 0.25 mg tablet | $0.122 per unit 15 mg softgel |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once