What the FDA labels say about taking them together
Brentuximab vedotin and ketoconazole
Brentuximab vedotin's FDA label of November 11, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name brentuximab vedotin. The brentuximab vedotin label: “Drugs on ADCETRIS CYP3A4 Inhibitors: Co-administration of ADCETRIS with ketoconazole, a potent CYP3A4 inhibitor, increased exposure to MMAE, which may increase the risk of adverse reaction.”
Check it at the source: the brentuximab vedotin FDA label on DailyMed (effective November 11, 2025, SEAGEN INC.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the brentuximab vedotin label say about ketoconazole?
Brentuximab vedotin label, drug interactionsDrugs on ADCETRIS CYP3A4 Inhibitors: Co-administration of ADCETRIS with ketoconazole, a potent CYP3A4 inhibitor, increased exposure to MMAE [see Clinical Pharmacology (12.3) ], which may increase the risk of adverse reaction.
Source: FDA drug label (ADCETRIS), BLA125388 (Seattle Genetics), as published by SEAGEN INC., effective November 11, 2025 (SPL set 3904f8dd-1aef-3490-e48f-bd55f32ed67f), via openFDA; the full label on DailyMed
What does the ketoconazole label say about brentuximab vedotin?
Ketoconazole's label (effective January 28, 2026) does not name brentuximab vedotin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Brentuximab vedotin | Ketoconazole | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once