What the FDA labels say about taking them together
Bosentan and glyburide
Bosentan's FDA label of November 17, 2025 names glyburide in its contraindications section, and glyburide's label names bosentan too. The bosentan label: “An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentan.”
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc).
What does the bosentan label say about glyburide?
Bosentan label, contraindicationsAn increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentan.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the glyburide label say about bosentan?
Glyburide label, contraindicationsTreated with bosentan.
Glyburide label, drug interactionsAn increased incidence of elevated liver enzymes was observed in patients receiving glyburide concomitantly with bosentan.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Glyburide | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0643 per tablet 5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once