What the FDA labels say about taking them together
Bosentan and gemfibrozil
Gemfibrozil's FDA label of April 10, 2026 names bosentan in its drug interactions section; the bosentan label PlainMeds reads does not name gemfibrozil. The gemfibrozil label: “(D) OATP1B1 substrates: Gemfibrozil is an inhibitor of OATP1B1 transporter and may increase exposure of drugs that are substrates of OATP1B1.”
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC).
What does the bosentan label say about gemfibrozil?
Bosentan's label (effective November 17, 2025) does not name gemfibrozil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the gemfibrozil label say about bosentan?
Gemfibrozil label, drug interactions(D) OATP1B1 substrates: Gemfibrozil is an inhibitor of OATP1B1 transporter and may increase exposure of drugs that are substrates of OATP1B1 (e.g., atrasentan, atorvastatin, bosentan, ezetimibe, fluvastatin, glyburide, SN-38 [active metabolite of irinotecan], rosuvastatin, pitavastatin, pravastatin, rifampin, valsartan, olmesartan).
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Gemfibrozil | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | High cholesterol, Heart attack and coronary artery disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.104 per tablet 600 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once