What the FDA labels say about taking them together
Bosentan and ethinyl estradiol/ferrous bisglycinate/levonorgestrel
Ethinyl estradiol/ferrous bisglycinate/levonorgestrel's FDA label of January 9, 2025 names bosentan in its drug interactions section; the bosentan label PlainMeds reads does not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel. The ethinyl estradiol/ferrous bisglycinate/levonorgestrel label: “Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate …”
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the ethinyl estradiol/ferrous bisglycinate/levonorgestrel FDA label on DailyMed (effective January 9, 2025, Lupin Pharmaceuticals, Inc.).
What does the bosentan label say about ethinyl estradiol/ferrous bisglycinate/levonorgestrel?
Bosentan's label (effective November 17, 2025) does not name ethinyl estradiol/ferrous bisglycinate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/ferrous bisglycinate/levonorgestrel label say about bosentan?
Ethinyl estradiol/ferrous bisglycinate/levonorgestrel label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John's wort.
Source: FDA drug label (MINZOYA), Lupin Pharmaceuticals, Inc., effective January 9, 2025 (SPL set d5ebd7fa-c388-4619-8dcb-e862e4ce5285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Ethinyl estradiol/ferrous bisglycinate/levonorgestrel | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | Birth control |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $3.45 per tablet 28 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once