What the FDA labels say about taking them together
Bosentan and elbasvir/grazoprevir
Elbasvir/grazoprevir's FDA label of March 13, 2026 names bosentan in its drug interactions section; the bosentan label PlainMeds reads does not name elbasvir/grazoprevir. The elbasvir/grazoprevir label: “Co-administration of ZEPATIER with bosentan may lead to reduced therapeutic effect of ZEPATIER. Co-administration is not recommended.”
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC).
What does the bosentan label say about elbasvir/grazoprevir?
Bosentan's label (effective November 17, 2025) does not name elbasvir/grazoprevir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the elbasvir/grazoprevir label say about bosentan?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Endothelin Antagonists: Bosentan; Effect on Concentration ↓ = decrease, ↑ = increase: ↓ EBR ↓ GZR; Clinical Comment: Co-administration of ZEPATIER with bosentan may lead to reduced therapeutic effect of ZEPATIER. Co-administration is not recommended.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Elbasvir/grazoprevir | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | Hepatitis C |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once