What the FDA labels say about taking them together
Bosentan and dienogest/estradiol
Dienogest/estradiol's FDA label of June 26, 2024 names bosentan in its drug interactions section; the bosentan label PlainMeds reads does not name dienogest/estradiol. The dienogest/estradiol label: “Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and …”
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the dienogest/estradiol FDA label on DailyMed (effective June 26, 2024, Bayer HealthCare Pharmaceuticals Inc.).
What does the bosentan label say about dienogest/estradiol?
Bosentan's label (effective November 17, 2025) does not name dienogest/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the dienogest/estradiol label say about bosentan?
Dienogest/estradiol label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St. John’s wort.
Source: FDA drug label (Natazia), Bayer HealthCare Pharmaceuticals Inc., effective June 26, 2024 (SPL set 02c91fba-9c47-43ef-ac78-e82369798834), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Dienogest/estradiol | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | Birth control |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $8.46 per tablet 28 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once