What the FDA labels say about taking them together
Bosentan and darunavir
Darunavir's FDA label of August 29, 2025 names bosentan in its drug interactions section; the bosentan label PlainMeds reads does not name darunavir.
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the bosentan label say about darunavir?
Bosentan's label (effective November 17, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the darunavir label say about bosentan?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: bosentan; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ bosentan; Clinical Comment: Co-administration of bosentan in patients on PREZISTA/ritonavir: In patients who have been receiving PREZISTA/ritonavir for at least 10 days, start bosentan at 62.5 mg once daily or every other day based upon individual tolerability. Co-administration of PREZISTA/ritonavir in patients on bosentan: Discontinue use of bosentan at least 36 hours prior to initiation of PREZISTA/ritonavir. After at least 10 days following the initiation of PREZISTA/ritonavir, resume bosentan at 62.5 mg once daily or every other day based upon individual tolerability.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Darunavir | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once