What the FDA labels say about taking them together
Bleomycin and brentuximab vedotin
Brentuximab vedotin's FDA label of November 11, 2025 names bleomycin in its contraindications section; the bleomycin label PlainMeds reads does not name brentuximab vedotin. The brentuximab vedotin label: “CONTRAINDICATIONS ADCETRIS is contraindicated with concomitant bleomycin due to pulmonary toxicity.”
Check it at the source: the bleomycin FDA label on DailyMed (effective October 10, 2024, Fresenius Kabi USA, LLC); the brentuximab vedotin FDA label on DailyMed (effective November 11, 2025, SEAGEN INC.).
What does the bleomycin label say about brentuximab vedotin?
Bleomycin's label (effective October 10, 2024) does not name brentuximab vedotin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Bleomycin), Fresenius Kabi USA, LLC, effective October 10, 2024 (SPL set b5806c40-12ce-48e3-8abd-9f8997ef4428), via openFDA; the full label on DailyMed
What does the brentuximab vedotin label say about bleomycin?
Brentuximab vedotin label, contraindicationsCONTRAINDICATIONS ADCETRIS is contraindicated with concomitant bleomycin due to pulmonary toxicity (e.g., interstitial infiltration and/or inflammation) [see Adverse Reactions (6.1) ].
Source: FDA drug label (ADCETRIS), BLA125388 (Seattle Genetics), as published by SEAGEN INC., effective November 11, 2025 (SPL set 3904f8dd-1aef-3490-e48f-bd55f32ed67f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bleomycin | Brentuximab vedotin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $26.45 per vial 15 unit vial | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once