What the FDA labels say about taking them together
Bisoprolol and rifampin
Bisoprolol's FDA label of March 11, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name bisoprolol. The bisoprolol label: “Concurrent use of rifampin increases the metabolic clearance of bisoprolol fumarate, resulting in a shortened elimination half-life of bisoprolol fumarate.”
Check it at the source: the bisoprolol FDA label on DailyMed (effective March 11, 2026, Micro Labs Limited); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the bisoprolol label say about rifampin?
Bisoprolol label, drug interactionsConcurrent use of rifampin increases the metabolic clearance of bisoprolol fumarate, resulting in a shortened elimination half-life of bisoprolol fumarate.
Source: FDA drug label (Bisoprolol), Micro Labs Limited, effective March 11, 2026 (SPL set c3ee566c-74c4-45f4-a947-526a7313e326), via openFDA; the full label on DailyMed
What does the rifampin label say about bisoprolol?
Rifampin's label (effective February 11, 2026) does not name bisoprolol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bisoprolol | Rifampin | |
|---|---|---|
| Labeled for | High blood pressure | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.114 per tablet 5 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once