What the FDA labels say about taking them together
Bisoprolol and clonidine
Bisoprolol's FDA label of March 11, 2026 names clonidine in its drug interactions section; clonidine's label does not name bisoprolol itself but warns about its class (Beta blockers).
Check it at the source: the bisoprolol FDA label on DailyMed (effective March 11, 2026, Micro Labs Limited); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the bisoprolol label say about clonidine?
Bisoprolol label, drug interactionsIn patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that bisoprolol fumarate be discontinued for several days before the withdrawal of clonidine.
Source: FDA drug label (Bisoprolol), Micro Labs Limited, effective March 11, 2026 (SPL set c3ee566c-74c4-45f4-a947-526a7313e326), via openFDA; the full label on DailyMed
What does the clonidine label say about bisoprolol?
Clonidine's label does not name bisoprolol itself; it warns about its class (Beta blockers):
Clonidine label, drug interactionsMonitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g. , digitalis, calcium channel blockers and beta-blockers.
Clonidine label, warningsThe likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bisoprolol | Clonidine | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, ADHD, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.114 per tablet 5 mg tablet | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once