What the FDA labels say about taking them together
Bexarotene and gemfibrozil
Bexarotene's FDA label of April 30, 2020 names gemfibrozil in its drug interactions section; the gemfibrozil labels PlainMeds reads (2) do not name bexarotene. The bexarotene label: “Because of a potential drug-drug interaction, avoid gemfibrozil use with TARGRETIN [ see Drug Interactions ].”
Check it at the source: the bexarotene FDA label on DailyMed (effective April 30, 2020, Bausch Health US, LLC); the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC).
What does the bexarotene label say about gemfibrozil?
Bexarotene label, drug interactionsDRUG INTERACTIONS Effect of Other Drugs on TARGRETIN Gemfibrozil: Concomitant administration of TARGRETIN and gemfibrozil resulted in increases in plasma concentrations of bexarotene.
Bexarotene label, warnings and precautionsBecause of a potential drug-drug interaction, avoid gemfibrozil use with TARGRETIN [ see Drug Interactions (7) ].
Targretin label (Bausch Health US, LLC, February 3, 2020), drug interactionsSimilarly, based on data that gemfibrozil increases bexarotene concentrations following oral bexarotene administration, concomitant gemfibrozil could increase bexarotene plasma concentrations.
Source: FDA drug label (Targretin, NDA021056), Bausch Health US, LLC, effective February 3, 2020 (SPL set d35b4697-3f3b-4aa1-b5d9-153993e83811), via openFDA
Source: FDA drug label (Targretin), Bausch Health US, LLC, effective April 30, 2020 (SPL set 1d056725-0576-4338-8089-6336e768ccdc), via openFDA; the full label on DailyMed
What does the gemfibrozil label say about bexarotene?
Gemfibrozil's label (effective April 10, 2026) and its 1 other brand-application label do not name bexarotene in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bexarotene | Gemfibrozil | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | High cholesterol, Heart attack and coronary artery disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.104 per tablet 600 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once