What the FDA labels say about taking them together
Betaxolol and clonidine
Betaxolol's FDA label of December 20, 2023 names clonidine in its drug interactions section; clonidine's label does not name betaxolol itself but warns about its class (Beta blockers).
Check it at the source: the betaxolol FDA label on DailyMed (effective December 20, 2023, Epic Pharma LLC); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the betaxolol label say about clonidine?
Betaxolol label, drug interactionsShould it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine.
Source: FDA drug label (Betaxolol), Epic Pharma LLC, effective December 20, 2023 (SPL set bf716efe-0a9f-43b1-9d8a-c69330b82e18), via openFDA; the full label on DailyMed
What does the clonidine label say about betaxolol?
Clonidine's label does not name betaxolol itself; it warns about its class (Beta blockers):
Clonidine label, drug interactionsMonitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g. , digitalis, calcium channel blockers and beta-blockers.
Clonidine label, warningsThe likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Betaxolol | Clonidine | |
|---|---|---|
| Labeled for | High blood pressure, Glaucoma | High blood pressure, ADHD, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.591 per tablet 10 mg tablet | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once