What the FDA labels say about taking them together
Berotralstat and etonogestrel
Berotralstat's FDA label of August 20, 2026 names etonogestrel in its drug interactions section; the etonogestrel label PlainMeds reads does not name berotralstat. The berotralstat label: “Desogestrel Concomitant use of ORLADEYO with desogestrel increases exposure to etonogestrel, the active metabolite of desogestrel, and may increase the risk of desogestrel-associated adverse reactions.”
Check it at the source: the berotralstat FDA label on DailyMed (effective August 20, 2026, BioCryst Pharmaceuticals, Inc.); the etonogestrel FDA label on DailyMed (effective May 28, 2026, Organon LLC).
What does the berotralstat label say about etonogestrel?
Berotralstat label, drug interactionsDesogestrel Concomitant use of ORLADEYO with desogestrel increases exposure to etonogestrel, the active metabolite of desogestrel, and may increase the risk of desogestrel-associated adverse reactions.
Source: FDA drug label (Orladeyo), BioCryst Pharmaceuticals, Inc., effective August 20, 2026 (SPL set 3527ece1-e7e0-40b1-b0c5-6baeb0deabeb), via openFDA; the full label on DailyMed
What does the etonogestrel label say about berotralstat?
Etonogestrel's label (effective May 28, 2026) does not name berotralstat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nexplanon), Organon LLC, effective May 28, 2026 (SPL set 487f8a62-e142-457c-97cc-2e398fde7594), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Berotralstat | Etonogestrel | |
|---|---|---|
| Labeled for | n/a | Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once