What the FDA labels say about taking them together
Benztropine and clozapine
Clozapine's FDA label of June 6, 2025 names benztropine in its drug interactions section; the benztropine label PlainMeds reads does not name clozapine. The clozapine label: “Anticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to …”
Check it at the source: the benztropine FDA label on DailyMed (effective January 9, 2026, ScieGen Pharmaceuticals Inc); the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.).
What does the benztropine label say about clozapine?
Benztropine's label (effective January 9, 2026) does not name clozapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Benztropine Mesylate), ScieGen Pharmaceuticals Inc, effective January 9, 2026 (SPL set 1ead16a7-88ed-407d-b25a-0d9a1d9da5ef), via openFDA; the full label on DailyMed
What does the clozapine label say about benztropine?
Clozapine label, drug interactionsAnticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity (e.g., benztropine, cyclobenzaprine, diphenhydramine) can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to hypomotility.
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Benztropine | Clozapine | |
|---|---|---|
| Labeled for | Parkinson's disease | Schizophrenia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0753 per tablet 1 mg tablet | $0.610 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once