What the FDA labels say about taking them together
Benzoyl peroxide and tazarotene
Tazarotene's FDA label (Fabior) of March 3, 2026 names benzoyl peroxide in its drug interactions section; the benzoyl peroxide labels PlainMeds reads (2) do not name tazarotene. The tazarotene label: “Concomitant use with oxidizing agents, such as benzoyl peroxide, may cause degradation of tazarotene and may reduce the clinical efficacy of tazarotene.”
Check it at the source: the benzoyl peroxide FDA label on DailyMed (effective July 31, 2026); the tazarotene FDA label on DailyMed (effective November 13, 2025, Almirall, LLC).
What does the benzoyl peroxide label say about tazarotene?
Benzoyl peroxide's label (effective July 31, 2026) and its 1 other brand-application label do not name tazarotene in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Terminator 10), AcneFree, LLC, effective July 31, 2026 (SPL set c06778b6-0ed6-7d82-e053-2a95a90a2ef8), via openFDA; the full label on DailyMed
What does the tazarotene label say about benzoyl peroxide?
Fabior label (Mayne Pharma, March 3, 2026), drug interactionsConcomitant use with oxidizing agents, such as benzoyl peroxide, may cause degradation of tazarotene and may reduce the clinical efficacy of tazarotene.
Source: FDA drug label (Fabior, NDA202428), Mayne Pharma, effective March 3, 2026 (SPL set ae0afed7-1d60-45fd-a08b-8db094618521), via openFDA
Source: FDA drug label (Tazorac), NDA020600 (Chartwell Rx), as published by Almirall, LLC, effective November 13, 2025 (SPL set 4e4e4b81-420e-4492-8a74-80b692a80057), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Benzoyl peroxide | Tazarotene | |
|---|---|---|
| Labeled for | Acne | Psoriasis, Acne |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0469 per gram 10% wash | $6.11 per gram 0.1% gel |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once