What the FDA labels say about taking them together
Benzalkonium and riboflavin 5-phosphate ophthalmic
Riboflavin 5-phosphate ophthalmic's FDA label (Epioxa Cross-Linking) of November 18, 2025 names benzalkonium in its contraindications section; the benzalkonium label PlainMeds reads does not name riboflavin 5-phosphate ophthalmic. The riboflavin 5-phosphate ophthalmic label: “Hypersensitivity EPIOXA HD and EPIOXA are contraindicated in patients with known hypersensitivity to benzalkonium chloride or any ingredients in EPIOXA HD and EPIOXA.”
Check it at the source: the benzalkonium FDA label on DailyMed (effective November 19, 2025); the riboflavin 5-phosphate ophthalmic FDA label on DailyMed (effective July 24, 2026).
What does the benzalkonium label say about riboflavin 5-phosphate ophthalmic?
Benzalkonium's label (effective November 19, 2025) does not name riboflavin 5-phosphate ophthalmic in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dial Antibacterial Hydrating Coconut Milk), Henkel Corporation, effective November 19, 2025 (SPL set 43f9be89-b434-75da-e063-6294a90a1864), via openFDA; the full label on DailyMed
What does the riboflavin 5-phosphate ophthalmic label say about benzalkonium?
Epioxa Cross-Linking label (Glaukos Corporation, November 18, 2025), contraindicationsHypersensitivity EPIOXA HD and EPIOXA are contraindicated in patients with known hypersensitivity to benzalkonium chloride or any ingredients in EPIOXA HD and EPIOXA.
Source: FDA drug label (Epioxa Cross-Linking, NDA219910), Glaukos Corporation, effective November 18, 2025 (SPL set 13cefc46-337c-41a3-b113-106bfe553bbb), via openFDA
Source: FDA drug label (Photrexa Cross-linking Kit), Glaukos Corporation, effective July 24, 2026 (SPL set f82cfe92-1a24-11e3-8ffd-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Benzalkonium | Riboflavin 5-phosphate ophthalmic | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once