What the FDA labels say about taking them together
Bendamustine and obinutuzumab
Bendamustine's FDA label of May 11, 2026 names obinutuzumab in its warnings and precautions section, and obinutuzumab's label names bendamustine too.
Check it at the source: the bendamustine FDA label on DailyMed (effective May 11, 2026, Meitheal Pharmaceuticals Inc.); the obinutuzumab FDA label on DailyMed (effective December 19, 2025, Genentech, Inc.).
What does the bendamustine label say about obinutuzumab?
Bendamustine label, warnings and precautionsLeukoencephalopathy (PML) Progressive multifocal leukoencephalopathy (PML), including fatal cases, have occurred following treatment with bendamustine, primarily in combination with rituximab or obinutuzumab [see Adverse Reactions ( 6.2 )].
Source: FDA drug label (Bendamustine Hydrochloride, NDA215033), Apotex Corp, effective September 9, 2026 (SPL set 085dd54c-4212-d879-afef-ee52732a48c0), via openFDA
Source: FDA drug label (Bendamustine), Meitheal Pharmaceuticals Inc., effective May 11, 2026 (SPL set 40f6f58d-d9ac-4f65-9fc7-16984bf1f180), via openFDA; the full label on DailyMed
What does the obinutuzumab label say about bendamustine?
Obinutuzumab label, warnings and precautionsCLL and FL In GALLIUM, more Grade 3 to 5 infections were reported in the recipients of GAZYVA and bendamustine (117/410 patients, 29%) as compared to GAZYVA plus CHOP or CVP (43/281 patients, 15%).
Source: FDA drug label (Gazyva), Genentech, Inc., effective December 19, 2025 (SPL set df12ceb2-5b4b-4ab5-a317-2a36bf2a3cda), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bendamustine | Obinutuzumab | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once