What the FDA labels say about taking them together
Benazepril/hydrochlorothiazide and methotrexate
Benazepril/hydrochlorothiazide's FDA label of February 24, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name benazepril/hydrochlorothiazide. The benazepril/hydrochlorothiazide label: “Antineoplastic agents: Concomitant use of thiazide diuretics may reduce renal excretion of cytotoxic agents and enhance their myelosuppressive effects.”
Check it at the source: the benazepril/hydrochlorothiazide FDA label on DailyMed (effective February 24, 2026, Validus Pharmaceuticals LLC); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the benazepril/hydrochlorothiazide label say about methotrexate?
Benazepril/hydrochlorothiazide label, drug interactionsAntineoplastic agents (e.g., cyclophosphamide, methotrexate): Concomitant use of thiazide diuretics may reduce renal excretion of cytotoxic agents and enhance their myelosuppressive effects.
Source: FDA drug label (Lotensin HCT), Validus Pharmaceuticals LLC, effective February 24, 2026 (SPL set 94c4536f-e28e-48b1-8336-b3939917e99d), via openFDA; the full label on DailyMed
What does the methotrexate label say about benazepril/hydrochlorothiazide?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name benazepril/hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Benazepril/hydrochlorothiazide | Methotrexate | |
|---|---|---|
| Labeled for | High blood pressure | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.222 per tablet 20-12.5 mg tablet | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once