What the FDA labels say about taking them together
Benazepril/hydrochlorothiazide and cyclophosphamide
Benazepril/hydrochlorothiazide's FDA label of February 24, 2026 names cyclophosphamide in its drug interactions section; cyclophosphamide's label does not name benazepril/hydrochlorothiazide itself but warns about its class (ACE inhibitors, Thiazide diuretics). The benazepril/hydrochlorothiazide label: “Antineoplastic agents: Concomitant use of thiazide diuretics may reduce renal excretion of cytotoxic agents and enhance their myelosuppressive effects.”
Check it at the source: the benazepril/hydrochlorothiazide FDA label on DailyMed (effective February 24, 2026, Validus Pharmaceuticals LLC); the cyclophosphamide FDA label on DailyMed (effective January 19, 2026, Amneal Pharmaceuticals LLC).
What does the benazepril/hydrochlorothiazide label say about cyclophosphamide?
Benazepril/hydrochlorothiazide label, drug interactionsAntineoplastic agents (e.g., cyclophosphamide, methotrexate): Concomitant use of thiazide diuretics may reduce renal excretion of cytotoxic agents and enhance their myelosuppressive effects.
Source: FDA drug label (Lotensin HCT), Validus Pharmaceuticals LLC, effective February 24, 2026 (SPL set 94c4536f-e28e-48b1-8336-b3939917e99d), via openFDA; the full label on DailyMed
What does the cyclophosphamide label say about benazepril/hydrochlorothiazide?
Cyclophosphamide's label does not name benazepril/hydrochlorothiazide itself; it warns about its class (ACE inhibitors, Thiazide diuretics):
Cyclophosphamide label, drug interactionsDrugs that Potentiate Cyclophosphamide Toxicities Toxicity Drugs Increased hematotoxicity and/or immunosuppression ● ACE inhibitors:
Cyclophosphamide label, drug interactionsDrugs that Potentiate Cyclophosphamide Toxicities Toxicity Drugs Increased hematotoxicity and/or immunosuppression ● ACE inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ●
Source: FDA drug label (Cyclophosphamide), Amneal Pharmaceuticals LLC, effective January 19, 2026 (SPL set 520bfe39-dfd5-4a20-9a37-80078afded0d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Benazepril/hydrochlorothiazide | Cyclophosphamide | |
|---|---|---|
| Labeled for | High blood pressure | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.222 per tablet 20-12.5 mg tablet | $1.67 per capsule 50 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once