What the FDA labels say about taking them together
Belumosudil and midazolam
Belumosudil's FDA label of April 7, 2026 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name belumosudil. The belumosudil label: “Concomitant use of REZUROCK with sensitive CYP3A substrates (e.g., midazolam) is predicted to increase CYP3A substrate exposure, which may increase the risk of adverse reactions related to these substrates.”
Check it at the source: the belumosudil FDA label on DailyMed (effective April 7, 2026, Kadmon Pharmaceuticals, LLC); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the belumosudil label say about midazolam?
Belumosudil label, drug interactionsConcomitant use of REZUROCK with sensitive CYP3A substrates (e.g., midazolam) is predicted to increase CYP3A substrate exposure [see Clinical Pharmacology (12.3) ], which may increase the risk of adverse reactions related to these substrates.
Source: FDA drug label (Rezurock), Kadmon Pharmaceuticals, LLC, effective April 7, 2026 (SPL set 102e4ef4-7f84-4e34-8df1-479c24d1575d), via openFDA; the full label on DailyMed
What does the midazolam label say about belumosudil?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name belumosudil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Belumosudil | Midazolam | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once