What the FDA labels say about taking them together
Belimumab and methotrexate
Belimumab's FDA label of August 21, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name belimumab.
Check it at the source: the belimumab FDA label on DailyMed (effective August 21, 2026); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the belimumab label say about methotrexate?
Belimumab label, drug interactionsIn clinical trials, BENLYSTA was administered concomitantly with other drugs, including corticosteroids, antimalarials, immunomodulatory and immunosuppressive agents (including azathioprine, cyclophosphamide, methotrexate, and mycophenolate), angiotensin pathway antihypertensives, HMG‑CoA reductase inhibitors (statins), and/or non-steroidal anti-inflammatory drugs (NSAIDs) without evidence of a clinically meaningful effect of these concomitant medications on belimumab pharmacokinetics.
Source: FDA drug label (BENLYSTA), GlaxoSmithKline LLC, effective August 21, 2026 (SPL set 2fa3c528-1777-4628-8a55-a69dae2381a3), via openFDA; the full label on DailyMed
What does the methotrexate label say about belimumab?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name belimumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Belimumab | Methotrexate | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once