What the FDA labels say about taking them together
Baclofen and morphine
Baclofen's FDA label (Lioresal (Baclofen)) of December 9, 2022 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name baclofen. The baclofen label: “Interactions attributed to the combined use of GABLOFEN and epidural morphine include hypotension and dyspnea.”
Check it at the source: the baclofen FDA label on DailyMed (effective August 12, 2024, Zydus Lifesciences Limited); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the baclofen label say about morphine?
Lioresal (Baclofen) label (Amneal Pharmaceuticals LLC, December 9, 2022), drug interactionsInteractions attributed to the combined use of LIORESAL INTRATHECAL and epidural morphine include hypotension and dyspnea.
Source: FDA drug label (Lioresal (Baclofen), NDA020075), Amneal Pharmaceuticals LLC, effective December 9, 2022 (SPL set 6f3bdcc0-ffc8-4911-8c35-958c8103a2c5), via openFDA
Source: FDA drug label (Gablofen, NDA022462), Piramal Critical Care Inc, effective May 7, 2026 (SPL set 00d3e846-dd92-448d-9ab8-6a07be823cc1), via openFDA
Source: FDA drug label (Baclofen), Zydus Lifesciences Limited, effective August 12, 2024 (SPL set bb5c6faa-2933-44d1-8706-8302150be734), via openFDA; the full label on DailyMed
What does the morphine label say about baclofen?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name baclofen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Baclofen | Morphine | |
|---|---|---|
| Labeled for | Muscle spasms and spasticity | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.032 per tablet 10 mg tablet | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once