What the FDA labels say about taking them together
Azithromycin and nifedipine
Nifedipine's FDA label of December 24, 2024 names azithromycin in its drug interactions section; the azithromycin labels PlainMeds reads (4) do not name nifedipine. The nifedipine label: “CYP3A inhibitors CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin, grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in …”
Check it at the source: the azithromycin FDA label on DailyMed (effective December 4, 2025, Bionpharma Inc.); the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited).
What does the azithromycin label say about nifedipine?
Azithromycin's label (effective December 4, 2025) and its 3 other brand-application labels do not name nifedipine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Azithromycin), Bionpharma Inc., effective December 4, 2025 (SPL set 859bb02c-a4bc-46fa-9fc9-def1219b5dfb), via openFDA; the full label on DailyMed
What does the nifedipine label say about azithromycin?
Nifedipine label, drug interactionsCYP3A inhibitors CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Azithromycin | Nifedipine | |
|---|---|---|
| Labeled for | Bacterial infections | High blood pressure, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.266 per tablet 250 mg tablet | $0.130 per tablet 30 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once