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What the FDA labels say about taking them together

Azathioprine and certolizumab

Certolizumab's FDA label of February 24, 2026 names azathioprine in its warnings and precautions section; the azathioprine label PlainMeds reads does not name certolizumab. The certolizumab label: “The potential risk of using a TNF blocker in combination with azathioprine or 6-MP should be carefully considered.”

Check it at the source: the azathioprine FDA label on DailyMed (effective November 8, 2025, Sebela Pharmaceuticals Inc.); the certolizumab FDA label on DailyMed (effective February 24, 2026, UCB, Inc.).

What does the azathioprine label say about certolizumab?

Azathioprine's label (effective November 8, 2025) does not name certolizumab in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (IMURAN), NDA016324 (Legacy), as published by Sebela Pharmaceuticals Inc., effective November 8, 2025 (SPL set 606101a0-6244-7eff-e053-2a91aa0acadd), via openFDA; the full label on DailyMed

What does the certolizumab label say about azathioprine?

Certolizumab label, warnings and precautions

The potential risk of using a TNF blocker in combination with azathioprine or 6-MP should be carefully considered.

Source: FDA drug label (Cimzia), BLA125160 (Ucb Inc), as published by UCB, Inc., effective February 24, 2026 (SPL set b4c2c9dc-a0bb-4d64-a667-a67ebe88392d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

17Azathioprine generic labelers
0Certolizumab generic labelers
AzathioprineCertolizumab
Labeled forOrgan transplant rejection, Rheumatoid arthritisRheumatoid arthritis, Crohn's disease and ulcerative colitis, Psoriasis
Boxed warningYesYes
Pharmacy cost (NADAC)$0.124 per tablet 50 mg tablet$6,094.02 per syringe 2x200 mg/mL syringe kit
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?