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What the FDA labels say about taking them together

Azathioprine and belimumab

Belimumab's FDA label of August 21, 2026 names azathioprine in its drug interactions section; the azathioprine label PlainMeds reads does not name belimumab.

Check it at the source: the azathioprine FDA label on DailyMed (effective November 8, 2025, Sebela Pharmaceuticals Inc.); the belimumab FDA label on DailyMed (effective August 21, 2026).

What does the azathioprine label say about belimumab?

Azathioprine's label (effective November 8, 2025) does not name belimumab in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (IMURAN), NDA016324 (Legacy), as published by Sebela Pharmaceuticals Inc., effective November 8, 2025 (SPL set 606101a0-6244-7eff-e053-2a91aa0acadd), via openFDA; the full label on DailyMed

What does the belimumab label say about azathioprine?

Belimumab label, drug interactions

In clinical trials, BENLYSTA was administered concomitantly with other drugs, including corticosteroids, antimalarials, immunomodulatory and immunosuppressive agents (including azathioprine, cyclophosphamide, methotrexate, and mycophenolate), angiotensin pathway antihypertensives, HMG‑CoA reductase inhibitors (statins), and/or non-steroidal anti-inflammatory drugs (NSAIDs) without evidence of a clinically meaningful effect of these concomitant medications on belimumab pharmacokinetics.

Source: FDA drug label (BENLYSTA), GlaxoSmithKline LLC, effective August 21, 2026 (SPL set 2fa3c528-1777-4628-8a55-a69dae2381a3), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

17Azathioprine generic labelers
0Belimumab generic labelers
AzathioprineBelimumab
Labeled forOrgan transplant rejection, Rheumatoid arthritisn/a
Boxed warningYesNo
Pharmacy cost (NADAC)$0.124 per tablet 50 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?